Possible Causes of and Measures to Minimise Risks of Abscesses Following DTP Vaccination

Registration and analysis of adverse events following immunisation (AEFIs) allow for objective assessment systematisation AEFI causes, promotion vaccination safety. Development abscesses after DTP is a fairly common AEFI, however, they are not included in the “Side effects” part patient information leaflet vaccine. The aim study was to analyse reasons abscess development elaborate recommendations on enhancing vaccine review literature data, solicited reports AEFIs, investigation submitted Scientific Centre Expert Evaluation Medicinal Products during 2014–2018 suggests that associated with may be caused by reactogenicity, quality defects arising production or distribution, administration errors healthcare personnel. Lack documents medical institutions does rule out any identified reasons. minimisation risks requires control vaccines, maintenance cold chain transportation storage, compliance aseptic regulations administration. Additional pharmacovigilance measures will also help enhance safety: improvement standardisation data collection post-vaccination period, obligatory inclusion thickness children’s subcutaneous adipose tissue (weight, body mass index) length needle used reports. It advisable add risk vaccine, update “Dosage regimen route” “Precautions” parts order minimise risk. Personnel facilities performing should made aware importance providing detailed AEFIs subsequent analysis.